FBXL5-mediated degradation of single-stranded DNA-binding protein hSSB1 controls DNA damage response

Human single-strand (ss) DNA binding proteins 1 (hSSB1) has been shown to participate in DNA damage response and maintenance of genome stability by regulating the initiation of ATM-dependent signaling. ATM phosphorylates hSSB1 and prevents hSSB1 from ubiquitin-proteasome-mediated degradation. Howeve...

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Bibliographische Detailangaben
Hauptverfasser: Chen, Zhi-Wei, Liu, Bin, Tang, Nai-Wang, Xu, Yun-Hua, Ye, Xiang-Yun, Li, Zi-Ming, Niu, Xiao-Min, Shen, Sheng-Ping, Lu, Shun, Xu, Ling
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191430/
https://ncbi.nlm.nih.gov/pubmed/25249620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku876
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