The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain

Viral RNA-dependent RNA polymerases (RdRps) responsible for the replication of single-strand RNA virus genomes exert their function in the context of complex replication machineries. Within these replication complexes the polymerase activity is often highly regulated by RNA elements, proteins or oth...

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Bibliographic Details
Main Authors: Potisopon, Supanee, Priet, Stéphane, Collet, Axelle, Decroly, Etienne, Canard, Bruno, Selisko, Barbara
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191377/
https://ncbi.nlm.nih.gov/pubmed/25209234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku666
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