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Specific mutations in the estrogen receptor change the properties of antiestrogens to full agonists.

The estrogen receptor (ER) stimulates transcription of target genes by means of its two transcriptional activation domains, AF-1 in the N-terminal part of the receptor and AF-2 in its ligand-binding domain. AF-2 activity is dependent upon a putative amphipathic alpha-helix between residues 538 and 5...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Mahfoudi, A, Roulet, E, Dauvois, S, Parker, M G, Wahli, W
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1995
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41912/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7753783/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.10.4206
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