Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers.

We describe in this report experiments in vivo that demonstrate that antiestrogens promote DNA binding of the estrogen receptor without efficiently inducing transcription. When the receptor is modified to carry a foreign unregulated transactivation domain, transcription can be induced efficiently by...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Pham, T A, Elliston, J F, Nawaz, Z, McDonnell, D P, Tsai, M J, O'Malley, B W
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51398/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2014231/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.8.3125
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