Specific mutations in the estrogen receptor change the properties of antiestrogens to full agonists.
The estrogen receptor (ER) stimulates transcription of target genes by means of its two transcriptional activation domains, AF-1 in the N-terminal part of the receptor and AF-2 in its ligand-binding domain. AF-2 activity is dependent upon a putative amphipathic alpha-helix between residues 538 and 5...
में बचाया:
| में प्रकाशित: | Proc Natl Acad Sci U S A |
|---|---|
| मुख्य लेखकों: | , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
National Academy of Sciences
1995
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41912/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7753783/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.10.4206 |
| टैग: |
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