Serum cholesterol selectively regulates glucocorticoid sensitivity through activation of JNK

Glucocorticoids (Gc) are potent anti-inflammatory agents with wide clinical application. We have previously shown that increased serum concentration significantly attenuates regulation of a simple Gc-responsive reporter. We now find that glucocorticoid receptor (GR) regulation of some endogenous tra...

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Autors principals: Yang, Nan, Caratti, Giorgio, Ince, Louise M, Poolman, Toryn M, Trebble, Peter J, Holt, Cathy M, Ray, David W, Matthews, Laura C
Format: Artigo
Idioma:Inglês
Publicat: Bioscientifica Ltd 2014
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191185/
https://ncbi.nlm.nih.gov/pubmed/25161081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-14-0456
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