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Maternally transmitted mitochondrial DNA mutations can reduce lifespan

We recently showed that germline transmission of mitochondrial DNA mutations via the oocyte cause aggravation of aging phenotypes in prematurely aging mtDNA mutator (PolgA(mut/mut)) mice. We discovered that 32% of these mice also exhibit stochastic disturbances of brain development, when maternal mt...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ross, Jaime M., Coppotelli, Giuseppe, Hoffer, Barry J., Olson, Lars
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190956/
https://ncbi.nlm.nih.gov/pubmed/25299268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06569
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