Discovery of 3-Arylcoumarin-tetracyclic Tacrine Hybrids as Multifunctional Agents against Parkinson’s Disease

[Image: see text] A series of multifunctional directed 3-arylcoumarin-tetracyclic tacrine derivatives was designed and synthesized for the treatment of Parkinson’s disease (PD). A number of derivatives (18, 19, 20, 21, and 24) demonstrated significant reduction of aggregation of “human” alpha-synucl...

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Autori principali: Sashidhara, Koneni V., Modukuri, Ram K., Jadiya, Pooja, Rao, K. Bhaskara, Sharma, Tanuj, Haque, Rizwanul, Singh, Deependra Kumar, Banerjee, Dibyendu, Siddiqi, Mohammad Imran, Nazir, Aamir
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2014
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190629/
https://ncbi.nlm.nih.gov/pubmed/25313319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500222g
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