Partial rescue of V1V2 mutant infectivity by HIV-1 cell-cell transmission supports the domain’s exceptional capacity for sequence variation

BACKGROUND: Variable loops 1 and 2 (V1V2) of the HIV-1 envelope glycoprotein gp120 perform two key functions: ensuring envelope trimer entry competence and shielding against neutralizing antibodies. While preserving entry functionality would suggest a high need for V1V2 sequence optimization and con...

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Bibliografske podrobnosti
Main Authors: Brandenberg, Oliver F, Rusert, Peter, Magnus, Carsten, Weber, Jacqueline, Böni, Jürg, Günthard, Huldrych F, Regoes, Roland R, Trkola, Alexandra
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2014
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190450/
https://ncbi.nlm.nih.gov/pubmed/25287422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-014-0075-y
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