Widespread B cell perturbations in HIV-1 infection afflict naive and marginal zone B cells

Perturbations in B cells are a hallmark of HIV-1 infection. This is signified by increased numbers of exhausted CD21(neg) memory B cells, driven by continuous antigen-specific and bystander activation. Using high-dimensional flow cytometry, we demonstrate that this exhausted phenotype is also preval...

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Bibliographic Details
Published in:J Exp Med
Main Authors: Liechti, Thomas, Kadelka, Claus, Braun, Dominique L., Kuster, Herbert, Böni, Jürg, Robbiani, Melissa, Günthard, Huldrych F., Trkola, Alexandra
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2019
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719425/
https://ncbi.nlm.nih.gov/pubmed/31221742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181124
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