A novel hydrolysis-resistant lipophilic folate derivative enables stable delivery of targeted liposomes in vivo

Instability of targeting ligand is a roadblock towards successful development of folate targeted liposomes. Folate ligands have been linked to polyethylene glycol (PEG) and cholesterol by an amide bond to form folate-CONH-PEG-CONH-Cholesterol (F-CONH-PEG-CONH-Chol), which is subject to hydrolysis. T...

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Hlavní autoři: Huang, Yifei, Yang, Tan, Zhang, Wendian, Lu, Yao, Ye, Peng, Yang, Guang, Li, Bin, Qi, Shibo, Liu, Yong, He, Xingxing, Lee, Robert J, Xu, Chuanrui, Xiang, Guangya
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2014
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4189705/
https://ncbi.nlm.nih.gov/pubmed/25302024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S69115
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