Co-delivery of Bmi1 small interfering RNA with ursolic acid by folate receptor-targeted cationic liposomes enhances anti-tumor activity of ursolic acid in vitro and in vivo

Overexpression of Bmi1 gene is an important feature of cancer stem cell in various human tumors. Therefore, Bmi1 gene can be a potential target for small interfering RNA (siRNA) mediated cancer therapy. Ursolic acid (UA) as a natural product plays a pivotal role in anti-tumor field, although its per...

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Vydáno v:Drug Deliv
Hlavní autoři: Li, Weijie, Yan, Ruicong, Liu, Yong, He, Chuanchuan, Zhang, Xiaojuan, Lu, Yao, Khan, Muhammad Waseem, Xu, Chuanrui, Yang, Tan, Xiang, Guangya
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6711155/
https://ncbi.nlm.nih.gov/pubmed/31366257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2019.1645244
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