5′RUNX1-3′USP42 chimeric gene in acute myeloid leukemia can occur through an insertion mechanism rather than translocation and may be mediated by genomic segmental duplications

BACKGROUND: The runt-related transcription factor 1 (RUNX1) gene is a transcription factor that acts as a master regulator of hematopoiesis and represents one of the most frequent targets of chromosomal rearrangements in human leukemias. The t(7;21)(p22;q22) rearrangement generating a 5′RUNX1-3′USP4...

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Détails bibliographiques
Auteurs principaux: Zagaria, Antonella, Anelli, Luisa, Coccaro, Nicoletta, Tota, Giuseppina, Casieri, Paola, Cellamare, Angelo, Minervini, Angela, Minervini, Crescenzio Francesco, Brunetti, Claudia, Cumbo, Cosimo, Specchia, Giorgina, Albano, Francesco
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2014
Sujets:
Case Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4189616/
https://ncbi.nlm.nih.gov/pubmed/25298786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13039-014-0066-7
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