SKF-83959 is not a highly-biased functionally selective D(1) dopamine receptor ligand with activity at phospholipase C

SKF-83959 [6-chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine] is reported to be a functionally selective dopamine D(1) receptor ligand with high bias for D(1)-mediated phospholipase C (PLC) versus D(1)-coupled adenylate cyclase signaling. This signaling bias is p...

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Bibliographic Details
Main Authors: Lee, Sang-Min, Kant, Andrew, Blake, Daniel, Murthy, Vishakantha, Boyd, Kevin, Wyrick, Steven J., Mailman, Richard B.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188748/
https://ncbi.nlm.nih.gov/pubmed/24929112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2014.05.042
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