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SKF-83959 is not a highly-biased functionally selective D(1) dopamine receptor ligand with activity at phospholipase C
SKF-83959 [6-chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine] is reported to be a functionally selective dopamine D(1) receptor ligand with high bias for D(1)-mediated phospholipase C (PLC) versus D(1)-coupled adenylate cyclase signaling. This signaling bias is p...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4188748/ https://ncbi.nlm.nih.gov/pubmed/24929112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2014.05.042 |
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