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Mechanism of Orlistat Hydrolysis by the Thioesterase of Human Fatty Acid Synthase

[Image: see text] Fatty acid synthase (FASN), the sole protein capable of de novo synthesis of free fatty acids, is overexpressed in a wide variety of human cancers and is associated with poor prognosis and aggressiveness of these cancers. Orlistat, an FDA-approved drug for obesity treatment that in...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Fako, Valerie E., Zhang, Jian-Ting, Liu, Jing-Yuan
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Chemical Society 2014
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188697/
https://ncbi.nlm.nih.gov/pubmed/25309810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cs500956m
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