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Inhibition of the Thioesterase Activity of Human Fatty Acid Synthase by 1,4- and 9,10-Diones

Fatty acid synthase (FASN) is the enzyme that synthesizes fatty acids de novo in human cells. Although FASN is generally expressed at low levels in most normal tissues, its expression is highly upregulated in many cancers. Consistent with this notion, inhibition of FASN activity has demonstrated pot...

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Detalhes bibliográficos
Publicado no:Chem Pharm Bull (Tokyo)
Main Authors: Odens, Herman, Lowther, Todd, Kridel, Steven, Watts, Laura, Filipponi, Lauren, Schmitt, Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441091/
https://ncbi.nlm.nih.gov/pubmed/25177021
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