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Synergism between Basic Asp49 and Lys49 Phospholipase A(2) Myotoxins of Viperid Snake Venom In Vitro and In Vivo

Two subtypes of phospholipases A(2) (PLA(2)s) with the ability to induce myonecrosis, ‘Asp49’ and ‘Lys49’ myotoxins, often coexist in viperid snake venoms. Since the latter lack catalytic activity, two different mechanisms are involved in their myotoxicity. A synergism between Asp49 and Lys49 myotox...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Mora-Obando, Diana, Fernández, Julián, Montecucco, Cesare, Gutiérrez, José María, Lomonte, Bruno
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188610/
https://ncbi.nlm.nih.gov/pubmed/25290688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109846
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