Role of enzymatic activity in muscle damage and cytotoxicity induced by Bothrops asper Asp49 phospholipase A(2) myotoxins: are there additional effector mechanisms involved?

Viperid venoms often contain mixtures of Asp49 and Lys49 PLA(2) myotoxin isoforms, relevant to development of myonecrosis. Given their difference in catalytic activity, mechanistic studies on each type require highly purified samples. Studies on Asp49 PLA(2)s have shown that enzyme inactivation usin...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Mora-Obando, Diana, Díaz, Cecilia, Angulo, Yamileth, Gutiérrez, José María, Lomonte, Bruno
Materialtyp: Artigo
Språk:Inglês
Publicerad: PeerJ Inc. 2014
Ämnen:
Biochemistry
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178460/
https://ncbi.nlm.nih.gov/pubmed/25276503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.569
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