Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance.

We sought to examine mechanisms responsible for increased vasoconstriction that occurs during development of nitroglycerin tolerance. Rabbits were treated for 3 days with nitroglycerin patches (0.4 mg/hr), and their aortic segments were studied in organ chambers. This treatment resulted in attenuate...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Münzel, T, Giaid, A, Kurz, S, Stewart, D J, Harrison, D G
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41885/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7539147/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.11.5244
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