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Deletion Mutations Conferring Substrate Spectrum Extension in the Class A β-Lactamase
We describe four new deletion mutations in a class A β-lactamase PenA in Burkholderia thailandensis, each conferring an extended substrate spectrum. Single-amino-acid deletions T171del, I173del, and P174del and a two-amino-acid deletion, R165_T167delinsP, occurred in the omega loop, increasing the f...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2014
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4187959/ https://ncbi.nlm.nih.gov/pubmed/25049254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02648-14 |
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