Alveolar Macrophages and Neutrophils Are the Primary Reservoirs for Legionella pneumophila and Mediate Cytosolic Surveillance of Type IV Secretion

Legionella pneumophila, an intracellular pathogen responsible for the severe pneumonia Legionnaires' disease, uses its dot/icm-encoded type IV secretion system (T4SS) to translocate effector proteins that promote its survival and replication into the host cell cytosol. However, by introducing b...

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Main Authors: Copenhaver, Alan M., Casson, Cierra N., Nguyen, Hieu T., Fung, Thomas C., Duda, Matthew M., Roy, Craig R., Shin, Sunny
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2014
נושאים:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187856/
https://ncbi.nlm.nih.gov/pubmed/25092908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01891-14
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