Alveolar Macrophages and Neutrophils Are the Primary Reservoirs for Legionella pneumophila and Mediate Cytosolic Surveillance of Type IV Secretion

Legionella pneumophila, an intracellular pathogen responsible for the severe pneumonia Legionnaires' disease, uses its dot/icm-encoded type IV secretion system (T4SS) to translocate effector proteins that promote its survival and replication into the host cell cytosol. However, by introducing b...

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Bibliographic Details
Main Authors: Copenhaver, Alan M., Casson, Cierra N., Nguyen, Hieu T., Fung, Thomas C., Duda, Matthew M., Roy, Craig R., Shin, Sunny
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187856/
https://ncbi.nlm.nih.gov/pubmed/25092908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01891-14
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