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Differential Effects of Escherichia coli Subtilase Cytotoxin and Shiga Toxin 2 on Chemokine and Proinflammatory Cytokine Expression in Human Macrophage, Colonic Epithelial, and Brain Microvascular Endothelial Cell Lines

Subtilase cytotoxin (SubAB) is the prototype of a recently emerged family of AB5 cytotoxins produced by Shiga-toxigenic Escherichia coli (STEC). Its mechanism of action involves highly specific A-subunit-mediated proteolytic cleavage of the essential endoplasmic reticulum (ER) chaperone BiP. Our pre...

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מידע ביבליוגרפי
Main Authors: Wang, Hui, Rogers, Trisha J., Paton, James C., Paton, Adrienne W.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187808/
https://ncbi.nlm.nih.gov/pubmed/24914216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02120-14
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