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Plakophilin-2 Promotes Tumor Development by Enhancing Ligand-Dependent and -Independent Epidermal Growth Factor Receptor Dimerization and Activation

Epidermal growth factor (EGF) receptor (EGFR) has been implicated in tumor development and invasion. Dimerization and autophosphorylation of EGFR are the critical events for EGFR activation. However, the regulation of EGF-dependent and EGF-independent dimerization and phosphorylation of EGFR has not...

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Main Authors: Arimoto, Kei-ichiro, Burkart, Christoph, Yan, Ming, Ran, Dan, Weng, Stephanie, Zhang, Dong-Er
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187709/
https://ncbi.nlm.nih.gov/pubmed/25113560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00758-14
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