Urocortin 2 stimulates nitric oxide production in ventricular myocytes via Akt- and PKA-mediated phosphorylation of eNOS at serine 1177

Urocortin 2 (Ucn2) is a cardioactive peptide exhibiting beneficial effects in normal and failing heart. In cardiomyocytes, it elicits cAMP- and Ca(2+)-dependent positive inotropic and lusitropic effects. We tested the hypothesis that, in addition, Ucn2 activates cardiac nitric oxide (NO) signaling a...

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Autors principals: Walther, Stefanie, Pluteanu, Florentina, Renz, Susanne, Nikonova, Yulia, Maxwell, Joshua T., Yang, Li-Zhen, Schmidt, Kurt, Edwards, Joshua N., Wakula, Paulina, Groschner, Klaus, Maier, Lars S., Spiess, Joachim, Blatter, Lothar A., Pieske, Burkert, Kockskämper, Jens
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2014
Matèries:
Cardiovascular Neurohormonal Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187402/
https://ncbi.nlm.nih.gov/pubmed/25015964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00694.2013
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