cAMP- and Ca(2+)/calmodulin-dependent protein kinases mediate inotropic, lusitropic and arrhythmogenic effects of urocortin 2 in mouse ventricular myocytes

BACKGROUND AND PURPOSE: Urocortin 2 is beneficial in heart failure, but the underlying cellular mechanisms are not completely understood. Here we have characterized the functional effects of urocortin 2 on mouse cardiomyocytes and elucidated the underlying signalling pathways and mechanisms. EXPERIM...

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Detalhes bibliográficos
Main Authors: Yang, Li-Zhen, Kockskämper, Jens, Khan, Shelina, Suarez, Jorge, Walther, Stefanie, Doleschal, Bernhard, Unterer, Gregor, Khafaga, Mounir, Mächler, Heinrich, Heinzel, Frank R, Dillmann, Wolfgang H, Pieske, Burkert, Spiess, Joachim
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2011
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031072/
https://ncbi.nlm.nih.gov/pubmed/20942811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.01067.x
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