Histone deacetylase 1 reduces NO production in endothelial cells via lysine deacetylation of NO synthase 3

The lysine acetylation state of nonhistone proteins may be regulated through histone deacetylases (HDACs). Evidence suggests that nitric oxide (NO) synthase 3 (NOS3; endothelial NOS) is posttranslationally lysine acetylated, leading to increased NO production in the endothelium. We tested the hypoth...

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Detalhes bibliográficos
Main Authors: Hyndman, Kelly A., Ho, Dao H., Sega, Martiana F., Pollock, Jennifer S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Rapid Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187392/
https://ncbi.nlm.nih.gov/pubmed/25015965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00243.2014
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