Carbocisteine Improves Histone Deacetylase 2 Deacetylation Activity via Regulating Sumoylation of Histone Deacetylase 2 in Human Tracheobronchial Epithelial Cells

Histone deacetylase (HDAC) 2 plays a vital role in modifying histones to mediate inflammatory responses, while HDAC2 itself is commonly regulated by post-translational modifications. Small ubiquitin-related modifier (SUMO), as an important PTM factor, is involved in the regulation of multiple protei...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Song, Yun, Chi, Dan-Yi, Yu, Ping, Lu, Juan-Juan, Xu, Jian-Rong, Tan, Pan-Pan, Wang, Bin, Cui, Yong-Yao, Chen, Hong-Zhuan
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400890/
https://ncbi.nlm.nih.gov/pubmed/30873037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00166
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