Discoidin domain receptor 2 germline gene deletion leads to altered heart structure and function in the mouse

Discoidin domain receptor 2 (DDR2) is a fibrillar collagen receptor that is expressed in mesenchymal cells throughout the body. In the heart, DDR2 is selectively expressed on cardiac fibroblasts. We generated a germline DDR2 knockout mouse and used this mouse to examine the role of DDR2 deletion on...

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Autors principals: Cowling, Randy T., Yeo, Seon Ju, Kim, In Jai, Park, Joong Il, Gu, Yusu, Dalton, Nancy D., Peterson, Kirk L., Greenberg, Barry H.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2014
Matèries:
Integrative Cardiovascular Physiology and Pathophysiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187391/
https://ncbi.nlm.nih.gov/pubmed/24993042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00142.2014
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