Modeling luminal breast cancer heterogeneity: combination therapy to suppress a hormone receptor-negative, cytokeratin 5-positive subpopulation in luminal disease

INTRODUCTION: Many Luminal breast cancers are heterogeneous, containing substantial numbers of estrogen (ER) and progesterone (PR) receptor-negative cells among the ER+ PR+ ones. One such subpopulation we call “Luminobasal” is ER-, PR- and cytokeratin 5 (CK5)-positive. It is not targeted for treatme...

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Bibliografske podrobnosti
Main Authors: Knox, Aaron J, Scaling, Allison L, Pinto, Mauricio P, Bliesner, Brian S, Haughian, James M, Abdel-Hafiz, Hany A, Horwitz, Kathryn B
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187339/
https://ncbi.nlm.nih.gov/pubmed/25116921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-014-0418-6
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