Endocytosis of collagen by hepatic stellate cells regulates extracellular matrix dynamics

Hepatic stellate cells (HSCs) generate matrix, which in turn may also regulate HSCs function during liver fibrosis. We hypothesized that HSCs may endocytose matrix proteins to sense and respond to changes in microenvironment. Primary human HSCs, LX2, or mouse embryonic fibroblasts (MEFs) [wild-type;...

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Detalhes bibliográficos
Main Authors: Bi, Yan, Mukhopadhyay, Dhriti, Drinane, Mary, Ji, Baoan, Li, Xing, Cao, Sheng, Shah, Vijay H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
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Call for Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187054/
https://ncbi.nlm.nih.gov/pubmed/25080486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00086.2014
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