PKG-1α leucine zipper domain defect increases pulmonary vascular tone: implications in hypoxic pulmonary hypertension

Pulmonary hypertension (PH) is a chronic disease characterized by a progressive increase in vasomotor tone, narrowing of the vasculature with structural remodeling, and increase in pulmonary vascular resistance. Current treatment strategies include nitric oxide therapy and methods to increase cGMP-m...

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Main Authors: Ramchandran, Ramaswamy, Raghavan, Aarti, Geenen, David, Sun, Miranda, Bach, Laura, Yang, Qiwei, Raj, J. Usha
Format: Artigo
Language:Inglês
Published: American Physiological Society 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187036/
https://ncbi.nlm.nih.gov/pubmed/25128522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00093.2014
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