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Simultaneous Deletion of p21(Cip1/Waf1) and Caspase-3 Accelerates Proliferation and Partially Rescues the Differentiation Defects of Caspase-3 Deficient Hematopoietic Stem Cells

Specialized blood cells are generated through the entire life of an organism by differentiation of a small number of hematopoietic stem cells (HSC). There are strictly regulated mechanisms assuring a constant and controlled production of mature blood cells. Although such mechanisms are not completel...

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Main Authors: Carrillo García, Carmen, Riedt, Tamara, Li, Jin, Dotten, Manuela, Brossart, Peter, Janzen, Viktor
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186822/
https://ncbi.nlm.nih.gov/pubmed/25286245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109266
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