Hematopoietic stem cell responsiveness to exogenous signals limited by Caspase-3

Limited responsiveness to inflammatory cytokines is a feature of adult hematopoietic stem cells, and contributes to the relative quiescence and durability of the stem cell population in vivo. Here we report that the executioner Caspase, Caspase-3, unexpectedly participates in that process. Mice defi...

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Autors principals: Janzen, Viktor, Fleming, Heather E, Riedt, Tamara, Karlsson, Göran, Riese, Mathew J, Celso, Cristina Lo, Reynolds, Griffin, Milne, Craig D, Paige, Christopher J, Karlsson, Stefan, Woo, Minna, Scadden, David T.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2991117/
https://ncbi.nlm.nih.gov/pubmed/18522851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2008.03.012
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