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Oncolytic adenovirus-expressed RNA interference of O(6)-methylguanine DNA methyltransferase activity may enhance the antitumor effects of temozolomide
Temozolomide (TMZ) is an example of an alkylating agent, which are known to be effective anticancer drugs for the treatment of various solid tumors, including glioma and melanoma. TMZ acts predominantly through the mutagenic product O(6)-methylguanine, a cytotoxic DNA lesion. The DNA repair enzyme,...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
D.A. Spandidos
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4186622/ https://ncbi.nlm.nih.gov/pubmed/25295108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2014.2442 |
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