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Assessment of the effect of potential antifibrotic compounds on total and αVβ6 integrin‐mediated TGF‐β activation

Transforming growth factor‐β (TGF‐β) plays an important role in the development of tissue fibrosis, and molecules inhibiting this pathway are attractive therapeutic targets for fibrotic diseases such as idiopathic pulmonary fibrosis (IPF). Activation of TGF‐β is the rate‐limiting step in TGF‐β bioav...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Porte, Joanne, Jenkins, Gisli
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186436/
https://ncbi.nlm.nih.gov/pubmed/25505594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.30
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