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Persistence of hepatitis B virus covalently closed circular DNA in hepatocytes: molecular mechanisms and clinical significance

Covalently closed circular DNA (cccDNA) is the transcriptional template of hepatitis B virus (HBV). Extensive research over the past decades has unveiled the important role of cccDNA in the natural history and antiviral treatment of chronic HBV infection. cccDNA can persist in patients recovering fr...

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Detalhes bibliográficos
Main Authors: Yang, Hung-Chih, Kao, Jia-Horng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4185362/
https://ncbi.nlm.nih.gov/pubmed/26038757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emi.2014.64
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