Low expression of Abelson interactor-1 is linked to acquired drug resistance in Bcr-Abl induced leukemia

The basis for persistence of leukemic stem cells in the bone marrow microenvironment (BMME) remains poorly understood. We present evidence that signaling crosstalk between α4 integrin and Abelson interactor-1 (Abi-1) is involved in acquisition of an anchorage-dependent phenotype and drug resistance...

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Hlavní autoři: Chorzalska, Anna, Salloum, Ibrahem, Shafqat, Hammad, Khan, Saad, Marjon, Philip, Treaba, Diana, Schorl, Christoph, Morgan, John, Bryke, Christine R., Falanga, Vincent, Zhao, Thing C., Reagan, John, Winer, Eric, Olszewski, Adam, Al-Homsi, Samer, Kouttab, Nicola, Dubielecka, Patrycja M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4185277/
https://ncbi.nlm.nih.gov/pubmed/24699303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.120
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