Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation

WAVE2 is a member of the Wiskott–Aldrich syndrome protein family of cytoskeletal regulatory proteins shown to link Rac activation to actin remodeling via induction of Arp 2/3 activity. WAVE2 is thought to be regulated by its positioning in a macromolecular complex also containing the Abelson-(Abl) i...

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Bibliographische Detailangaben
Hauptverfasser: Leng, Yan, Zhang, Jinyi, Badour, Karen, Arpaia, Enrico, Freeman, Spencer, Cheung, Pam, Siu, Michael, Siminovitch, Katherine
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2005
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC545868/
https://ncbi.nlm.nih.gov/pubmed/15657136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409120102
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