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Engineered Fc based antibody domains and fragments as novel scaffolds
Therapeutic monoclonal antibodies (mAbs) have been successful for therapy of a number of diseases mostly cancer and immune disorders. However, the vast majority of mAbs approved for clinical use are full size, typically in IgG1 format. These mAbs may exhibit relatively poor tissue penetration and re...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4185235/ https://ncbi.nlm.nih.gov/pubmed/24792384 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2014.04.018 |
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