BET protein antagonist JQ1 is synergistically lethal with FLT3 tyrosine kinase inhibitor (TKI) and overcomes resistance to FLT3-TKI in AML cells expressing FLT-ITD

Recently, treatment with BET (bromodomain and extraterminal) protein antagonist (BA) such as JQ1 has been shown to inhibit growth and induce apoptosis of human AML cells, including those expressing FLT3-ITD. Here, we demonstrate that co-treatment with JQ1 and the FLT3 tyrosine kinase inhibitor (TKI)...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Fiskus, Warren, Sharma, Sunil, Qi, Jun, Shah, Bhavin, Devaraj, Santhana G. T., Leveque, Christopher, Portier, Bryce P., Iyer, Swaminathan, Bradner, James E., Bhalla, Kapil N.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4185220/
https://ncbi.nlm.nih.gov/pubmed/25053825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0258
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker