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Site-specific human histone H3 methylation stability: fast K4me3 turnover
We employ stable isotope labelling and quantitative mass spectrometry to track histone methylation stability. We show that H3 trimethyl K9 and K27 are slow to be established on new histones and slow to disappear from old histones, with half-lives of multiple cell divisions. By contrast the transcrip...
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| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2014
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4184988/ https://ncbi.nlm.nih.gov/pubmed/24826939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201400060 |
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