CDC42 inhibition suppresses progression of incipient intestinal tumors

Mutations in the APC or β-catenin genes are well established initiators of colorectal cancer (CRC), yet modifiers that facilitate the survival and progression of nascent tumor cells are not well defined. Using genetic and pharmacological approaches in mouse CRC and human CRC xenograft models, we sho...

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Detalhes bibliográficos
Main Authors: Sakamori, Ryotaro, Yu, Shiyan, Zhang, Xiao, Hoffman, Andrew, Sun, Jiaxin, Das, Soumyashree, Vedula, Pavan, Li, Guangxun, Fu, Jiang, Walker, Francesca, Yang, Chung S., Yi, Zheng, Hsu, Wei, Yu, Da-Hai, Shen, Lanlan, Rodriguez, Alexis J., Taketo, Makoto M., Bonder, Edward M., Verzi, Michael P., Gao, Nan
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184946/
https://ncbi.nlm.nih.gov/pubmed/25113996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-0267
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