CDC42 inhibition suppresses progression of incipient intestinal tumors

Mutations in the APC or β-catenin genes are well established initiators of colorectal cancer (CRC), yet modifiers that facilitate the survival and progression of nascent tumor cells are not well defined. Using genetic and pharmacological approaches in mouse CRC and human CRC xenograft models, we sho...

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Huvudupphovsmän: Sakamori, Ryotaro, Yu, Shiyan, Zhang, Xiao, Hoffman, Andrew, Sun, Jiaxin, Das, Soumyashree, Vedula, Pavan, Li, Guangxun, Fu, Jiang, Walker, Francesca, Yang, Chung S., Yi, Zheng, Hsu, Wei, Yu, Da-Hai, Shen, Lanlan, Rodriguez, Alexis J., Taketo, Makoto M., Bonder, Edward M., Verzi, Michael P., Gao, Nan
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184946/
https://ncbi.nlm.nih.gov/pubmed/25113996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-0267
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