The potent and selective α4β2*/α6*-nicotinic acetylcholine receptor partial agonist 2-[5-[5-((S)Azetidin-2-ylmethoxy)-3-pyridinyl]-3-isoxazolyl]ethanol demonstrates antidepressive-like behavior in animal models and a favorable ADME-tox profile

Preclinical and clinical studies demonstrated that the inhibition of cholinergic supersensitivity through nicotinic antagonists and partial agonists can be used successfully to treat depressed patients, especially those who are poor responders to selective serotonin reuptake inhibitors (SSRIs). In o...

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Main Authors: Yu, Li-Fang, Brek Eaton, J, Zhang, Han-Kun, Sabath, Emily, Hanania, Taleen, Li, Guan-Nan, van Breemen, Richard B, Whiteaker, Paul, Liu, Qiang, Wu, Jie, Chang, Yong-Chang, Lukas, Ronald J, Brunner, Dani, Kozikowski, Alan P
Formato: Artigo
Idioma:Inglês
Publicado: BlackWell Publishing Ltd 2014
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184702/
https://ncbi.nlm.nih.gov/pubmed/25505580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.26
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