Genetic Variants in CYP2R1, CYP24A1, and VDR Modify the Efficacy of Vitamin D(3) Supplementation for Increasing Serum 25-Hydroxyvitamin D Levels in a Randomized Controlled Trial

CONTEXT: Adequate serum 25-hydroxyvitamin D concentrations, [25(OH)D], are required for optimal bone health, and low levels are associated with chronic diseases. OBJECTIVE: We investigated whether 41 candidate single nucleotide polymorphisms (SNPs) in vitamin D and calcium pathway genes (GC, DHCR7,...

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Hauptverfasser: Barry, Elizabeth L., Rees, Judy R., Peacock, Janet L., Mott, Leila A., Amos, Christopher I., Bostick, Roberd M., Figueiredo, Jane C., Ahnen, Dennis J., Bresalier, Robert S., Burke, Carol A., Baron, John A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2014
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JCEM Online: Advances in Genetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184076/
https://ncbi.nlm.nih.gov/pubmed/25070320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2014-1389
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