Dasatinib worsens the effect of cetuximab in combination with fractionated radiotherapy in FaDu- and A431-derived xenografted tumours

BACKGROUND: Cetuximab is often combined with radiotherapy in advanced SCCHN. Alternative routes bypassing inhibition of EGFR with cetuximab may overshadow the efficacy of this combination. We undertook this study to investigate a possible role of dasatinib in this scenario. METHODS: The SCC5, SCC25,...

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Detalhes bibliográficos
Main Authors: Baro, M, de Llobet, L I, Figueras, A, Skvortsova, I, Mesia, R, Balart, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183853/
https://ncbi.nlm.nih.gov/pubmed/25077442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.432
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