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Strategy for “Detoxification” of a Cancer-Derived Histone Mutant Based on Mapping Its Interaction with the Methyltransferase PRC2
[Image: see text] The histone methyltransferase PRC2 plays a central role in genomic stability and cellular development. Consequently, its misregulation has been implicated in several cancers. Recent work has shown that a histone H3 mutant, where the PRC2 substrate residue Lys27 is replaced by methi...
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| Główni autorzy: | , , , , , |
|---|---|
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Chemical
Society
2014
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| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4183613/ https://ncbi.nlm.nih.gov/pubmed/25180930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja5060934 |
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