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Metabolic programming of mesenchymal stromal cells by oxygen tension directs chondrogenic cell fate

Actively steering the chondrogenic differentiation of mesenchymal stromal cells (MSCs) into either permanent cartilage or hypertrophic cartilage destined to be replaced by bone has not yet been possible. During limb development, the developing long bone is exposed to a concentration gradient of oxyg...

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Bibliografische gegevens
Hoofdauteurs: Leijten, Jeroen, Georgi, Nicole, Moreira Teixeira, Liliana, van Blitterswijk, Clemens A., Post, Janine N., Karperien, Marcel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183286/
https://ncbi.nlm.nih.gov/pubmed/25205812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410977111
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